Research on the statistical methods for longitudinal data in diagnostic Lead Investigator: Fangyao Chen Institution : School of Public Health, Xi'an Jiaotong Universit E-Mail : chenfy@xjtu.edu.cn Proposal ID : 845 Proposal Description: My research works are mainly about the biostatistics methods for longitudinal data. This data would be used as a test data set for my work on the models for longitudinal data in diagnostic tests. My primary aim is to test the performance of a new model with the NACC data. Then, I want to make a comparison between my model and models already proposed. Finally, I also want to explore if there will be any new clinical or psychological index or their combinations which would be useful in the early diagnose of Alzheimer disease and other dementia disease. 1. The data will be used as a test data in the research works about the statistical methods for diagnostic test. 2. To discuss the difference between the chinese and non-chinese AD patients. 3. To explore potential biomarkers for the early diagnosis of AD.